leptin obesity toxic adipose residues and inflammation `metabolic syndrome´
Epidemiology of palsma lipids and the metabolic syndrome in multi ethnic population
Ngày tải lên :
12/09/2015, 10:42
... resistance in rats, and result in phosphoryation of serine/threonine residues on IRS-1 While the link between obesity and fatty acids and inflammation seem obvious, the link between obesity and elevated ... acids and b) inflammation 1.6.1 Fatty acids as the link between obesity and insulin resistance Adipose tissue was the site where excess energy was stored, in the form of triglycerides (TGs), and ... free fatty acids, amino acids and TNF-alpha, are associated with obesity and through a variety of mechanisms, result in the phosphorylation of serine and threonine residues on IRS-1 In turn, this...
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Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx
Ngày tải lên :
14/02/2014, 22:20
... inflammation of adipose tissue in obesity and related insulin resistance [15] Here, we focus on the roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases, and discuss whether these ... ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases The expression of ANGPTL2 and ANGPTL6 ⁄ AGF is induced in obese conditions ANGPTL2 induces chronic adipose tissue inflammation and ... serum levels and amelioration of diet-induced obesity and insulin resistance [14] Taken together, these findings suggest that ANGPTL6 ⁄ AGF in the circulation counteracts obesity and related insulin...
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Báo cáo Y học: Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice pdf
Ngày tải lên :
17/03/2014, 17:20
... the pivotal role of obesity and dyslipidemia in the development of the metabolic syndrome and heart disease, the functional interactions between adipose tissue and the lipid and lipoprotein transport ... Diet-induced obesity in ApoE3knock-in and C57BL/6 mice is associated with elevated plasma glucose, insulin and leptin levels Epidemiological and animal studies have established that central obesity ... intolerance and insulin resistance [20] In addition, obesity is accompanied by increased levels of leptin [38], a hormone that reduces appetite and may function as the link between obesity and hypertension...
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Báo cáo y học: " Carotid Intima-media thickness in childhood and adolescent obesity relations to abdominal obesity, high triglyceride level and insulin resistance"
Ngày tải lên :
25/10/2012, 11:40
... IMT was closely associated with obesity especially abdominal obesity in childhood and adolescence as confirmed by our correlation analysis and regression analysis Obesity has been demonstrated ... metabolism and chronic inflammation not only in adults but also in children and adolescents In our study, IMT was significantly related to lg (HOMA-IR) and TG in both bivariate correlation and multiple ... atherosclerosis begins in obese children and adolescents, and this tendency is intensified in the presence of MetS Obesity especially abdominal obesity, high TG level and insulin resistance are strong...
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Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx
Ngày tải lên :
18/02/2014, 11:20
... hydrogen bonds between K12 and the side chains of N10 and Q64, which maintain the unusual Ramachandran angles for the K12 residue, and a Ramachandran scatter plot for the K12 residues in 21 TIM structures ... residues showing critical hydrogen bonds at the dimer interface The residues in green are from subunit B and those in cyan are from subunit A The active site residues of P falciparum, yeast and ... triosephosphate isomerase Critical interactions between AÂ and AÂÂ [the guanidine group and aromatic residues of PfTIM (R98 F102)] and the BÂ guanidine and sulfur groups of GlTIM (R99 M103) are marked...
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Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx
Ngày tải lên :
19/02/2014, 12:20
... 4¢-phosphopantothenate binding residues Asn59, Ala179, Ala180 and Asp183 from one monomer and Arg55¢ from the adjacent monomer correspond to E coli CoaB residues Asn210, Ala275, Ala276, Asp279 and Arg206 A model ... and 450 nm Molecular mass information was obtained as described [6], determining the elution volumes of standard proteins and the void volume of the column The Superdex 200 PC 3.2/30 column and ... 271) 165 Materials and methods Plasmid construction In general, PCR amplifications were performed with VentDNA-polymerase (New England Biolabs) The entire sequences of the dfp and coaB coding regions...
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Báo cáo khoa học: Cold exposure and associated metabolic changes in adult tropical beetles exposed to fluctuating thermal regimes ppt
Ngày tải lên :
16/03/2014, 11:20
... °Cc, °CF20° and 20 °CF0°) Control beetles exhibited the lowest amounts of Glu and Lys, and the highest levels of Asn ⁄ Ser and Arg ⁄ Thr (Fig 1A,B) Gln was significantly lower in control and °Cc beetles ... reared in darkness at 20 °C and supplied with water and food ad libitum, consisting of moistened bran and dry dog food All the insects used for this study were between and months old at the beginning ... 70% ethanol and Fontainebleau sand, before adding 1.5 mL of 40% ethanol The homogenate was centrifuged for 10 at 4500 g and °C (Sigma 2-16 K, angle rotor 10 · 20, Sigma-Aldrich Co.), and the supernatant...
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Báo cáo khoa học: Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells ppt
Ngày tải lên :
16/03/2014, 14:20
... (N92Q or N324D) and double N-glycosylation sites (N92Q ⁄ N324D) Asn residues in the two potential N-glycosylation sites (92NFT94 and 324NVT326) are substituted by Gln and ⁄ or Asp residues in the ... These included mutants with Asp residues in the two active-site DTG motifs changed to Ala residues and mutants lacking the propeptide, putative ER-retention sequence, and N-glycosylation of this ... only the 46-kDa form, indicating that the 46-kDa and 42-kDa bands are pro-cathepsin E and mature cathepsin E, respectively To follow the biosynthesis and processing of wildtype cathepsin E, the transfected...
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Báo cáo khoa học: 2-Oxo acid dehydrogenase complexes in redox regulation Role of the lipoate residues and thioredoxin pot
Ngày tải lên :
17/03/2014, 09:20
... disulfide/dithiol group and the residues modulating its properties, (b) the interaction between the a3/310 and a1 helices and the length of the a1 helix and (c) the three charged residues on the thioredoxin ... concentrations of the reaction substrates and products, (b) kinetic properties of the component enzymes, E1, E2 and E3, and (c) their stoichiometry and interactions within the complex During ... 2-oxo acid and CoA (reactions 1–3) and the dihydrolipoate is reoxidized by NAD+ in a FAD-dependent process (reactions 4,5) The lipoate may be also reduced in the backward reactions (5 and 4), upon...
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Preventing Childhood Obesity in Early Care and Education Programs pdf
Ngày tải lên :
22/03/2014, 09:20
... Childhood Obesity in Early Care and Education Programs Preventing Childhood Obesity in Early Care and Education Programs Preventing Childhood Obesity in Early Care and Education Programs Selected Standards ... eating and positive exercise habits that prevent childhood obesity CFOC standards can assist early care and education programs, families, and community resources and agencies to develop and adopt ... Center for Health and Safety in Child Care and Early Education (NRC), and the U.S Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health...
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Báo cáo khóa học: Active site residues and mechanism of UDP-glucose dehydrogenase ppt
Ngày tải lên :
23/03/2014, 12:20
... Other active site residues that could potentially play roles in the hydride transfer and/ or hydrolysis steps were also identified These include Thr118, Glu141, Glu145, Lys204, Asn208, and Asp264 All ... proton acceptor (Fig 3B) In this case, Asn208 and Lys204 (presumably in the ammonium form) serve as hydrogen bond donors to the hydroxyl oxygen, and Thr118 and a ribose hydroxyl of NAD+ form hydrogen ... identity of the catalytic residues involved in hydrolysis of the thioester intermediate are harder to predict from these structures; however, Glu141 and Glu145 are potential candidates In this work,...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
Ngày tải lên :
18/06/2014, 15:20
... antagonizing flRAGE and other receptors by binding DAMPs and other ligands and inhibiting leukocyte recruitment in a variety of acute and chronic inflammatory conditions [4] Both esRAGE and sRAGE act ... sustain inflammation and impaired tumor elaboration and growth Thus, RAGE drives and promotes inflammatory responses during tumor growth at multiple stages and has a central role in chronic inflammation ... cytokines and proinflammatory adhesion molecules [24,67,68] Conclusion RAGE and its ligands play essential roles in inflammation, neurobiology, cancer, and numerous other conditions Each ligand distinctly...
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báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot
Ngày tải lên :
18/06/2014, 15:20
... necrosis and natriuretic peptides are well known indicators of cardiac dysfunction and filling pressures In addition, certain other biomarkers are known to be indicators of inflammation and apoptosis, ... manufacturer protocol and using standard curves and software The kits for NTproBNP (fmol/ml) were purchased from ALPCO Diagnostics, Salem, New Hampshire; for IL-6 (pg/ml) and TNFα (pg/ ml) from ... was non-random and uncontrolled in design Since inotropic agents are currently considered to carry excess risk and thus are used only when thought to be absolutely clinically necessary, randomization...
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báo cáo hóa học: " Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer''''s disease" potx
Ngày tải lên :
19/06/2014, 22:20
... analysis, data analysis and presentation and assisted with perfusions and animal care; OY performed immunohistochemistry and image analysis; DC assisted with the design of the study and manuscript preparation; ... study and data analysis, and manuscript preparation AJT developed the design of the study, guided study execution, directed data analysis, interpretation and presentation, and drafted and edited ... Pennsylvania, Philadelphia, PA, and Anna Erdei (Eotvos University, Budapest, Hungary) for the monoclonal anti mouse C3 antibody 2/ 16 and 2/11, and Jennifer Chen, Xiomara Fernandez, Anahit Ghochikyan,...
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báo cáo hóa học:" Nutrition and inflammation serum biomarkers are associated with 12-week mortality among malnourished adults initiating antiretroviral therapy in Zambia" potx
Ngày tải lên :
20/06/2014, 08:20
... albumin and hsCRP, and the hazard of death was non-linear (p < 0.10), and there was evidence that the association between albumin and the hazard of the combined endpoint of mortality and loss ... CN, EK, IZ and LM were responsible for study design and data collection MB, BS and JK performed the statistical analyses JC and EK performed the laboratory analyses JK, MB, EK, CW, JC and AM drafted ... relationship between the baseline nutrition or inflammation serum biomarker values and time to death The biomarkers were modelled as continuous variables and expanded using restricted cubic splines to...
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Báo cáo y học: "Allergy, Asthma, and Inflammation: Which Inflammatory Cell Type Is More Importan" doc
Ngày tải lên :
08/08/2014, 21:20
... cells and eosinophils synthesize, store, and release a similar profile of Th2 cytokines However, whereas mast cells store and release histamine following activation, eosinophils store and elease ... eosinophils in allergic asthma and the toxicity of their ranule- tored meg s diators indicated the need to focus on understanding eosinophil effector function in vitro and in vivo This resulted ... that T cell–dependent recruitment and activation of eosinophils and mast cells are a crucial step toward the control of arasite- nduced granulomas in tissues p i and expulsion of adult worms from...
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Báo cáo y học: "Comparison of prevalence of metabolic syndrome in hospital and community-based Japanese patients with schizophrenia" potx
Ngày tải lên :
09/08/2014, 01:21
... analysis SK and NYF contributed to study design and assisted in drafting the manuscript YS, IK and HY completed the initial survey construction and recruitment of participants MS, HF, TN and MH participated ... Demographic and clinical characteristics Demographic and clinical characteristics of the study population are shown in Table Schizophrenic outpatients were significantly younger and taller, and had ... This study was conducted between January 2007 and December 2008 Subjects were 759 inpatients (355 males and 404 females) and 427 outpatients (215 males and 212 females) from psychiatric hospitals...
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Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" ppsx
Ngày tải lên :
09/08/2014, 01:22
... Univariate analysis Patients in the LE and ME groups were older (P = 0.002) and had longer disease duration (P < 0.001) and higher ESR (P = 0.031) and HAQ (P < 0.001) and more frequent joint replacement ... syndrome and GC exposure, thus acting as potential confounders, included age (P = 0.001 and P = 0.002, respectively), RA disease duration (P = 0.008 and P < 0.001), ESR (P = 0.006 and P = 0.031), and ... conception and design of the project and in the analysis and interpretation of data and contributed substantially to the drafting of the manuscript VFP participated in the acquisition, analysis, and...
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Báo cáo y học: "Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation" potx
Ngày tải lên :
09/08/2014, 06:23
... postmenopausal RA, and to evaluate the relative importance and possible different mechanisms of estrogen deficiency versus joint inflammation for the induction of bone loss Materials and methods Mice ... A/S, Ry, Denmark) were kept, to 10 animals to a cage, under standard environmental conditions and were fed with standard laboratory chow and tap water ad libitum Castration OVX or sham operation ... proinflammatory cytokines tumor necrosis factor-α and IL-1, and by the production of RANKL by activated T-lymphocytes and fibroblasts Garnero and colleagues [21] found increased serum levels of...
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Báo cáo y học: "Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats" potx
Ngày tải lên :
09/08/2014, 07:20
... hematoxylin and eosin, and were examined microscopically We also performed the hematoxylin and eosin staining of tissue specimens of the liver and the kidney Two blinded observers evaluated cartilage and ... Velo GP: Copper and zinc status in rats and acute inflammation: focus on the inflamed area Agents Actions 1988, 24:356-364 Mandinova A, Soldi R, Graziani I, Bagala C, Bellum S, Landriscina M, Tarantini ... neutropenia, and osteoporosis TM was remarkably nontoxic when ceruloplasmin was lowered to 10–20% of baseline levels for up to 17 months of treatment, and the only drug-related toxicity observed...
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